How does air pollution destroy our sense of smell? Losing the sense of smell or anosmia can have a significant impact on our quality of life, and researchers say that air pollution plays a role in causing it.
How does air pollution destroy our sense of smell?
In this article we’re going to read about how does pollution destroy our sense of smell . The sense of smell is one of our richest and broadest windows to the world around us, which plays a vital role in what we taste and our social interactions, and even helps us recognize possible dangers. But the threat in the air we breathe can destroy our sense of smell.
Covid-19 has shown many people what it is like to lose the sense of smell. Loss of the sense of smell, which is called “anosmia”, can have a significant impact on our well-being and quality of life. But while a sudden respiratory infection may lead to a temporary loss of this important sense, the sense of smell may gradually deteriorate over many years due to air pollution.
Exposure to PM2.5 (the collective name for particulate air pollution that comes mainly from burning fuel in our vehicles, power plants, and homes) has previously been linked to olfactory disorders, but usually only in certain environments, writes the BBC. Industrial or occupational. But new research reveals the true scale of olfactory impairment caused by air pollution and the potential harm caused by the pollution we breathe in every day. The findings of this study are important for all of us.
In the lower part of the brain, just above the nasal cavities, is the olfactory bulb. This sensitive tissue has nerve endings and is essential for the diverse image we get of the world with the help of the sense of smell. The olfactory bulb is also our first line of defense against viruses and pollutants entering the brain. But when repeatedly exposed to harmful factors, this defense slowly weakens.
“Our data show a 1.6- to 1.7-fold increased risk of developing anosmia in conditions of persistent particulate matter pollution,” says Murugapan Ramanathan, a nasal disease specialist at Johns Hopkins School of Medicine in Baltimore. Ramanathan has been curious about whether there is a connection between suffering from anosmia and the level of air pollution where people live. The simple question that Ramanathan wanted to answer was this: Is the prevalence of anosmia higher in people who live in areas with higher PM2.5 pollution?
Until recently, there was little scientific research on this topic. A Mexican study from 2006 used the smell of coffee and oranges to show that residents of Mexico City, who are often exposed to air pollution, have a poorer sense of smell on average than people living in rural areas of the country.
With the help of colleagues including Genevieve Zhang, an epidemiologist who created a map of air pollution data in the Baltimore area, Ramanathan conducted a study using data from 2,690 patients who visited Johns Hopkins Hospital over a four-year period. About 20% of the mentioned patients had anosmia and most of them did not smoke. Smoking affects the sense of smell.

PM2.5 levels were higher in neighborhoods where patients with anosmia lived, compared to healthy control group participants. Even when the effect of age, sex, ethnicity, body mass index, and alcohol and tobacco use were taken into account, the same result was obtained: even a small increase in exposure to ambient PM2.5 may be associated with anosmia.
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These findings have been repeated in studies in other regions of the world. For example, a recent study in Brescia in northern Italy showed that the more teenagers and young adults were exposed to nitrogen dioxide (another pollutant produced when fossil fuels are burned, especially from vehicle engines), the more sensitive their noses were to odors. Another annual study in São Paulo, Brazil, also found that people who lived in areas with higher particle pollution had a poorer sense of smell.
How does air pollution destroy our sense of smell?
According to Ramanathan, there are two possible paths. One is that some pollution particles pass through the olfactory bulb and directly enter the brain and cause inflammation. “The olfactory nerves are in the brain, but there’s an opening at the base of the skull where small nerve fibers enter the nose,” says Ramanathan.
In 2016, a team of British researchers found the following metallic particles in human brain tissue that appeared to have passed through the olfactory bulb. Barbara Maher, a professor of environmental science at Lancaster University who led the study, said at the time that the particles were similar to those found in polluted air near busy streets. (Fireplaces and wood-burning stoves were also other possible sources).

Maher’s study shows that when tiny metal particles enter the brain, they can be toxic and cause oxidative brain damage that damages neural pathways; Although this is still theoretical. Another possible mechanism, says Ramanathan, may not even require pollution particles to enter the brain. Particles of pollution by constantly hitting the olfactory bulb, cause inflammation and damage to the nerves and destroy them slowly. Think of this situation as coastal erosion, where sand and salt waves gradually erode the shoreline. Let’s say those airwaves are full of pollution and the coastline is our nasal nerves.
Therefore, it is not surprising that anosmia mostly affects older people whose noses have been exposed to air pollution for a longer period. Interestingly, none of the Johns Hopkins patients lived in areas with excessive air pollution. Most of them lived in the green areas of Maryland, and none of them lived in highly polluted areas. This shows that even low levels of air pollution can cause problems in the long run.
A similar study was conducted separately by the Center for Aging Research at the Karolinska Institute in Stockholm. Postdoctoral researcher Ingrid Ekström was puzzled by findings from the early 2000s that showed more than 5.8 percent of adults in Sweden had anosmia and 19.1 percent had some form of smell disorder.
Knowing that the rate of anosmia is higher among the elderly, Ekstrom and colleagues designed a study using 3363 patients aged 60 years and older. Using sticks that gave off 16 common household odors, participants were scored based on the number of odors they could correctly identify.
As in the Baltimore study, participants’ home addresses were mapped based on urban air pollution, and here, too, a strong correlation was seen between higher pollution levels and poorer olfactory strength. “They had been exposed to pollution throughout their lives,” says Ekström. We don’t know exactly when their olfactory disorder started.” But he is confident that long-term exposure to pollution, even at low levels, has caused people’s olfactory disorders.
In 2021, the World Health Organization changed its health-based guidelines for the maximum annual average exposure to PM2.5 particles, changing it from 10 micrograms per cubic meter to 5 micrograms per cubic meter.
Stockholm, the capital of Sweden, is one of the few big cities in the world that is below the set level with an annual average of 4.2 micrograms per cubic meter. In contrast, Pakistan’s Islamabad has an annual average PM2.5 of 41.1 micrograms per cubic meter, while this average in Bloemfontein, South Africa is 42.3 micrograms per cubic meter.
This makes the Stockholm findings even more important: even Stockholm residents lose their sense of smell due to low pollution levels; How much worse can this problem be in areas where pollution levels are high? It’s also a reminder of how local pollution can be, both outdoors and indoors. Cooking and heating methods may expose some households to higher levels of pollution than their neighbors.
Meanwhile, modern combustion methods from vehicle engines to new wood stoves can produce tiny nanoparticles that barely register in PM2.5 readings, but are small enough to enter our bloodstream and brain tissue directly.
Air pollution is the cause of a quarter of deaths from heart disease and stroke and almost half of the deaths from lung diseases.
Maybe our sense of smell does not seem so alarming compared to the mentioned diseases. But Ramanathan and Ekström warn that the sense of smell and the problems caused by its lack are more important than they think.